Against Me! is a punk rock band formed in 1997 in Naples, Florida. Their first full-length album, released on No Idea Records in 2002, is Reinventing Axl Rose. They have released music on Misanthrope Records, Crasshole Records, Plan It X Records, Sabot Productions, No Idea Records, and Fat Wreck Chords. In December 2005, they signed with Sire Records, and released their major label debut, New Wave, on July 10, 2007.

Against Me! released their first live album (and last album before their 2007 Sire release) - titled Americans Abroad!!! Against Me!!! Live in London!!! - on August 22, 2006. The album was recorded at the Mean Fiddler in London, England. It features one previously unreleased song named "Americans Abroad".

Against Me! announced on their MySpace on December 29, 2006 their debut album on Sire, New Wave. The album is ten songs, stretching just over 30 minutes, and it was released on July 10, 2007. It debuted at #57 on the Billboard 200 the week of its release. Spin Magazine magazine named it the best album of 2007. The record featured their first chart single, "Thrash Unreal", which hit #11 on the US Modern Rock chart.

On August 13, 2007, Gabel was charged with battery in Tallahassee, Florida for an incident in which Gabel allegedly entered into a confrontation with a cafe patron, resulting in Gabel allegedly bashing the man's head against a cafe table, but Gabel claims nothing happened, except for a spilled drink. Gabel was permitted to perform at Against Me!'s concert that night, but was taken into custody immediately after. He was released on a $500 bail the next morning.

The band appeared on Late Night with Conan O' Brien for the second time on July 10, 2007, playing their single "Thrash Unreal", as well as appearing on The Late Show with David Letterman on August 29, 2007, playing the song "Stop!" AM! was also featured as MTV's artist of the week in December 2007. Throughout this time many songs off of New Wave were played in show previews and credits.

Ben Lee released his own tribute cover of the whole album on his website, and performed selections from it on his late 2007 tour of the United States.

In early 2008, the band supported the Foo Fighters on their American tour. During this tour, they also played three shows in smaller venues separate from the Foo Fighters tour to support the Harvest of Hope Foundation. All proceeds from these shows went directly to the organization.

In May 2008, Rolling Stone named Against Me! "Best Punk Band" on a list entitled The 125-Plus People, Places and Things Ruling the Rock & Roll Universe.

In April 2008, the band filmed a PSA for Rock the Vote about the issues that are important to them and why they vote.

On June 19, 2008, they performed "Up the Cuts" on the Tonight Show with Jay Leno. The band spent the Summer on the Warped Tour for the second time. They will tour Canada in September with Japanther and The Saint Alvia Cartel, and the United States in October with Ted Leo and the Pharmacists and Future of the Left. Gabel will then briefly tour solo with Chuck Ragan of Hot Water Music, Ben Nichols of Lucero, and Tim Barry of Avail. The band will briefly tour France, where the New Wave album was recently released for the first time as a deluxe edition, in December, and will head into the studio to record a New Wave follow-up in early 2009.